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Rabbit Anti-DAT antibody
Catalog Number : BYK-1714R
Quantity size : 0.1ml （dilute with pH 7.4 0.01 M PBS or antibody diluent ）
Background: Plasmalemmal neurotransmitter transporters sequester synaptic and peri synaptic transmitter into presynaptic elements. The Dopamine Transporter （DAT） is responsible for the reaccumulation of dopamine after it has been released. Levels of DAT protein expression are altered by chronic drug administration. The activity of the DAT reuptake carrier is sodium dependent, and it is suspected to play a role in such neurologic and psychiatric disorders as Parkinson's disease, Tourette's disease, schizophrenia, and addiction. It is a 12 transmembrane domain transporter with the N and C terminal regions located within the cytoplasm. Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.
Involvement in disease:
Defects in SLC6A3 are the cause of dystonia-parkinsonism infantile （DYTPRI） . It is a neurodegenerative disorder characterized by infantile onset of parkinsonism and dystonia. Other neurologic features include global developmental delay, bradikinesia and pyramidal tract signs.
Anti-DAT抗體,多巴胺轉運蛋白DAT抗體技術文章Specificity :
– Anti-DAT is a rabbit polyclonal antibody unconjugated
– specific for DAT of hu, mo, rat, cow
– use for western blotting,elisa,immunoprecipitation and immunohistochemistry
– Protein G affinity chromatography purification, purity :>95%
– Isotype: IgG
– mol wt: 36kDa
Application :
– Western blotting 1:100-500
– Immunohistochemistry 1:100-500
– IHC-P=1:100-500 IHC-F=1:100-500
– ELISA 1:500-1000
– Optimal working dilutions must be determined by the end user.
Storage: Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20℃. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least six weeks at 2-4 ℃
Anti-DAT抗體,多巴胺轉運蛋白DAT抗體技術文章Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
